SLC27 family of fatty acid transporters in GtoPdb v.2023.1

Role of fatty acid transporters in epidermis

Skin epidermis is an active site of lipid synthesis. The intercellular lipids of human stratum corneum (SC) are unique in composition and quite different from the lipids found in most biological membranes. The three major lipids in the SC are free fatty acids, cholesterol and ceramides. Fatty acids can be synthesized by keratinocytes de novo and, in addition, need to be taken up from the circul...

Fatty acid transporters in animal cells.

The mechanism by which fatty acids transverse the plasma membrane has been a controversial subject. Kinetic studies of fatty acid uptake suggested the presence of a protein carrier system in certain cells which exhibit rapid fatty acid influx and/or efflux such as hepatocytes, adipocytes and jejunal mucosal cells. Five plasma membrane proteins have been identified and proposed as candidates for...

Fatty acid transporters, transport and metabolism

James G. Nickerson, Hakam Alkhateeb, Carley R. Benton, James Lally, Jennifer Nickerson, Xiao-Xia Han, M. H. Wilson, Swati S. Jain, Laelie A. Snook, Jan. F.C. Glatz, Adrian Chabowski, Joost J.F.P. Luiken, and Arend Bonen From the 1 Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada, the Department of Laboratory Medical Sciences, Hashemite U...

A family of fatty acid transporters conserved from mycobacterium to man.

Long chain fatty acids (LCFAs) are an important source of energy for most organisms. They also function as blood hormones, regulating key metabolic functions such as hepatic glucose production. Although LCFAs can diffuse through the hydrophobic core of the plasma membrane into cells, this nonspecific transport cannot account for the high affinity and specific transport of LCFAs exhibited by cel...

Lipid content and fatty acid composition in some species of compositae family